张明亮 博士 讲师
地址：睢阳校区化学实验楼416
Email：moonlightzhang@163.com
教育经历
20011.9-2016.6，中国科学院大学（中国科学院成都有机化学研究所），理学博士
2007.9-2011.6，河南大学，理学学士
工作经历
2017.9至今，讲师
2016.6-2017.8，常州合全新药研发有限公司(药明康德全资子公司)，高级研究员
主讲课程
药物分离与纯化技术，化学信息学
研究方向
催化不对称合成，化学药物合成及工艺优化。
主持科研项目
[1] 广谱抗癌药Entrectinib的合成工艺研发及优化(编号202102310003)，河南省科技攻关计划项目，10万，2020.1-2021.12，结项
代表性研究成果（2015年以来）
1.论著
[1] Mingliang Zhang, Pin Zhao, Dongqing Wu*, Zhichao Qiu, Chenyue Zhao, Wenyu Zhang, Feng Li, Jing Zhou*, and Lantao Liu*. Brønsted Acid-Catalyzed Reaction of N-arylnaphthalen-2-amines with Quinone Esters for the Construction of Carbazole and C–N Axially Chiral Carbazole Derivatives.J. Org. Chem.2023,88, 5, 2841–285.
[2] Mingliang Zhang†, Pin Zhao†, Qilv Liu, Xinlei Liu, Jingya Hu, Dongqing Wu*and Lantao Liu*.Construction ofN-Ferrocene Substituted Benzodihydrooxazoles via a Catalyst-Free Aza-Michael Addition/C(sp3)-O Bond Formation Tandem Reaction.Molecules2023,28, 5615.
[3] Mingliang Zhang, Pin Zhao, Hao Yuan, An'an Zhang, Wenyu Zhang, Linlin Zheng, Dongqing Wu*, Lantao Liu*.Chinese Journal of Organic Chemistry,2021,41, 669-676.
[4] Ming-LiangZhang, Zhi-Jun Wu, Jian-qiang Zhao,Yuan Luo, Xiao-Ying Xu*,Xiao-Mei Zhang, Wei-Cheng Yuan*, Michael Addition-Lactonization of Arylacetyl Phosphonate toβ,γ-Unsaturatedα-Keto Esters for the Synthesis of Chiral syn-3,4-Dihydropyranones and 5,6-Dihydropyranones.Org.Lett.2016,18, 5110-5113.
[5] Ming-Liang Zhang,Lin Chen,Yong You,Zhen-Hua Wang,Deng-Feng Yue,Xiao-Mei Zhang,Xiao-Ying Xu*,Wei-Cheng Yuan*，Asymmetric Michael reaction of arylacetyl phosphonates to nitroalkenes with bifunctional amine-thiourea catalyst bearing multiple-hydrogen-bond donor: efficient construction of chiral α-substituted carboxylic ester compounds.Tetrahedron2016,72, 2677-2682.
[6] Ming-LiangZhang,Deng-Feng Yue,Zhen-Hua Wang,Yuan Luo,Xiao-Ying Xu*,Xiao-Mei Zhang,Wei-Cheng Yuan*, Organocatalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones with bifunctional amine-thiourea catalysts bearing multiple hydrogen-bond donors,Beilstein J. Org. Chem.2016,12, 295-300.
2.奖励
[1] 张明亮，《基于任务导向的高等学校化学信息学课程教学范式改革研究》，河南省教育科学研究优秀成果奖二等奖
